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	Provedor de dados BJPS (1) Genet. Mol. Biol. (1) Autor Altan,Cem (1) Borges,Kleiton Silva (1) Brassesco,María Sol (1) Gürten,Berna (1) Malta,Seyda (1) Scrideli,Carlos Alberto (1) Sezer,Ali Demir (1) Soares,Ademilson Espencer Egea (1) Tone,Luiz Gonzaga (1) Yenigül,Elçin (1) Mais... Palavra-chave Temozolomide (2) Anticancer (1) Chitosan (1) Cyclodextrin (1) Glioblastoma (1) Magnetite (1) Propolis (1) Targeting (1) U251 (1) U343 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2011 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Antiproliferative effects of Tubi-bee propolis in glioblastoma cell lines Genet. Mol. Biol. Borges,Kleiton Silva; Brassesco,María Sol; Scrideli,Carlos Alberto; Soares,Ademilson Espencer Egea; Tone,Luiz Gonzaga. Propolis is a resin formed by a complex chemical composition of substances that bees collect from plants. Since ancient times, propolis has been used in folk medicine, due to its biological properties, that include antimicrobial, anti-inflammatory, antitumoral and immunomodulatory activities. Glioblastoma is the most common human brain tumor. Despite the improvements in GBM standard treatment, patients' prognosis is still very poor. The aim of this work was to evaluate in vitro the Tubi-bee propolis effects on human glioblastoma (U251 and U343) and fibroblast (MRC-5) cell lines. Proliferation, clonogenic capacity and apoptosis were analyzed after treatment with 1 mg/mL and 2 mg/mL propolis concentrations for different time periods. Additionally,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Glioblastoma; Propolis; Temozolomide; U251; U343. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000200024 Targeting of temozolomide using magnetic nanobeads: an in vitro study BJPS Gürten,Berna; Yenigül,Elçin; Sezer,Ali Demir; Altan,Cem; Malta,Seyda. Temozolomide, a chemotherapeutic drug that is often administered for the treatment of brain cancer has severe side effects and a poor aqueous solubility. In order to decrease the detrimental effect of the drug over healthy cells, a novel drug delivery vehicle was developed where the therapeutic drug was encapsulated within the hydrophobic cavities of b-CD modified magnetite nanoparticles, which are embedded in chitosan nanobeads prepared by salt addition. In-vitro studies have shown that the magnetic properties of the novel delivery vehicle are adequate for targeted drug delivery applications under an external magnetic field. Additionally, an increase in the amount of chitosan was shown to exhibit a strong shielding effect over the magnetic properties of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Temozolomide; Magnetite; Cyclodextrin; Chitosan; Targeting; Anticancer. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100574 Registros recuperados: 2 Primeira ... 1 ... Última

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